Quick summary of glioblastoma multiforme (GBM) treatment

• Surgical resection followed by involved-field RT plus concurrent temozolomide followed by up to six cycles of adjuvant temozolomide. 
• Adjuvant temozolomide alone may be considered in elderly patients with poor performance status, especially for O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylated tumors. 
• Adjuvant radiation therapy alone may be considered in elderly patients with MGMT promoter UNmethylated tumors
• Bevacizumab is FDA approved for the treatment of recurrent glioblastoma. It's addition in the adjuvant setting didn't improve survival.