Quick summary of glioblastoma multiforme (GBM) treatment

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  • Surgical resection followed by involved-field RT plus concurrent temozolomide followed by up to six cycles of adjuvant temozolomide. 
  • Adjuvant temozolomide alone may be considered in elderly patients with poor performance status, especially for O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylated tumors. 
  • Adjuvant radiation therapy alone may be considered in elderly patients with MGMT promoter UNmethylated tumors
  • Bevacizumab is FDA approved for the treatment of recurrent glioblastoma. It's addition in the adjuvant setting didn't improve survival.



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