3 important Mutations and syndromes in oncology
- RET germline mutation is found in Multiple Endocrine Neoplasia Type II. - TP53 mutation is found in Li-Fraumeni syndrome. - MLH1 mutation is found in Lynch syndrome.
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Treatment of classical Hodgkin’s lymphoma Summary
Early stage favorable Hodgkin’s lymphoma · HD 10 trial: NEJM 2010: o 1370 pts, 4 arms: § 4 cycles of ABVD followed by 30 Gy § 4 cycles of ABVD followed by 20 Gy § 2 cycles of ABVD followed by 30 Gy § 2 cycles of ABVD followed by 20 Gy o No difference in freedom from treatment failure, OS at 5 yrs o 2 cycles of ABVD followed by 20 Gy should be the new standard of care Unfavorable characteristics Bulky disease (>10 cm or 1/3 max. transverse thorax diameter Extranodal site involvement 3 or more lymph node areas involved ESR > 50 mm/h or > 30 mm/hr with B symptoms. ...
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